Nature is launching an essay competition for readers aged 18 to 25. We invite you to tell us, in an essay of no more than 1,000 words, what scientific advance, big or small, you would most like to see in your lifetime, and why it matters to you. We want to feature the inspiring voices and ideas of the next generation. For further information see this website: https://www.nature.com/articles/d41586-019-01562-3.